XIAO sa

XIAO Sa

Ph.D., Professor

Contact

Address: College of Veterinary Medicine, Northwest A&F University

No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.

Email: saxiao@nwafu.edu.cn

Mobile: +86 18706825438

1. Education and Work Experience

2013 – present, Professor, College of Veterinary Medicine, Northwest A&F University

2007 – 2013, Research Associate, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, USA

2002 – 2006, Postdoctoral Fellow, Mount Sinai School of Medicine, New York, USA

1996 – 2001, Ph.D., Molecular Microbiology, Kyoto University, Japan.

1990 – 1996, Research Assistant, Institute of Genetics, Chinese Academy of Sciences

1986 – 1990, Bachelor, Animal Husbandry and Veterinary Medicine, College of Beijing Agriculture

2. Research and Teaching

Research interests:

Bio-characterization of avian paramyxoviruses, especially in Newcastle disease virus (NDV).

Molecular mechanism of NDV pathogenesis

RNA virus-host interactions

Engineering NDV as a vector for vaccine development and gene therapy

Teaching:

Veterinary Lemology, Veterinary Epidemiology, Avian Diseases for bachelor students.

Prevention and Control of Animal Epidemic Diseases for master students.

The theory and practice of animal disease preventing and control for doctoral students.

3. Memberships and Academic Services

Member of the American Society for Virology

4. Publications

Recent years:

1. Evasion of Host Antiviral Innate Immunity by Paramyxovirus Accessory Proteins. Wang C, Wang T, Duan L, Chen H, Hu R, Wang X, Jia Y, Chu Z, Liu H, Wang X, Zhang S, Xiao S, Wang J, Dang R, Yang Z*.  Front Microbiol. 2022; 12:790191.

2. Nian X, Li L, Ma X, Li X, Li W, Zhang N, Ohiolei JA, Li L, Dai G, Liu Y, Yan H, Fu B*, Xiao S*, Jia W*. Understanding pathogen-host interplay by expression profiles of lncRNA and mRNA in the liver of Echinococcus multilocularis-infected mice.  PLoS Negl Trop Dis.  2022; 16(5):e0010435.

3. Encephalomyocarditis Virus 2A Protein Inhibited Apoptosis by Interaction with Annexin A2 through JNK/c-Jun Pathway. Han R, Liang L, Qin T, Xiao S*, Liang R*.  Viruses. 2022; 14(2):359.

4. Identification of a new amino acid mutation in the HN protein of NDV involved in pathogenicity. Chen X, Jia Y, Wei N, Ye C, Hao H, Xiao S, Wang X, Liu H, Yang Z*.  Vet Res.  2021; 52(1):147.

5. Probiotics Isolated From Animals in Northwest China Improve the Intestinal Performance of Mice. Li Y, Jia D, Wang J, Li H, Yin X, Liu J, Wang J, Guan G, Luo J, Yin H, Xiao S, Li Y*.  Front Vet Sci. 2021; 8:750895.

6. Newcastle disease virus V protein interacts with hnRNP H1 to promote viral replication. Tong L, Chu Z, Gao X, Yang M, Adam FEA, Theodore DWP, Liu H, Wang X, Xiao S, Yang Z*.  Vet Microbiol. 2021; 260:109093.

7. Musashi1 inhibit the release of Newcastle disease viruses through preventing apoptosis of DF-1 cells. Yang M, Ma J, Chu Z, Cao X, Lu K, Shi X, Tong L, Yan C, Liu H, Wang X, Xiao S, Yang Z*.  Poult Sci. 2021; 100(7):101105.

8. Cellular CARD11 Inhibits the Fusogenic Activity of Newcastle Disease Virus via CBM Signalosome-Mediated Furin Reduction in Chicken Fibroblasts. Wang W, Wei Q, Hao Q, Zhang Y, Li Y, Bi Y, Jin Z, Liu H, Liu X, Yang Z*, Xiao S*.  Front Microbiol. 2021; 12:607451.

9. Comparative biology of two genetically closely related Newcastle disease virus strains with strongly contrasting pathogenicity. Chen X, Chen S, Chen H, Tian J, Zhao X, Jia Y, Xiao S, Wang X, Liu H, Yang Z*.  Vet Microbiol.  2021; 253:108977.

10. Identification of a potential neutralizing linear epitope of hemagglutinin-neuraminidase in Newcastle disease virus. Jin Z, Wei Q, Bi Y, Li Y, Huo N, Mou S, Wang W, Liu H, Yang Z, Chen H*, Xiao S*.  Virol J. 2021; 18(1):8.

11. Screening and mechanistic study of key sites of the hemagglutinin-neuraminidase protein related to the virulence of Newcastle disease virus. Yan C, Liu H, Jia Y, Prince-Theodore DW, Yang M, Addoma Adam FE, Ren J, Cao X, Wang X, Xiao S, Zhang S, Yang Z*.  Poult Sci.  2020; 99(7):3374-3384.

12. Liu WG, Luo J, Ren QY, Qu ZQ, Lin HL, Xu XF, Ni J, Xiao RH, Chen RG, Rashid M, Wu ZG, Tan YC, Qiu XF, Luo JX, Yin H, Wang H, Yang ZQ, Xiao S, Liu GY*. A Novel miRNA-hlo-miR-2-Serves as a Regulatory Factor That Controls Molting Events by Targeting CPR1 in  Haemaphysalis longicornis Nymphs.  Front Microbiol.  2020; 11:1098.

13. WangX, Jia Y, Ren J, Liu H, Xiao S, Wang X, Yang Z*. MicroRNA gga-miR-455-5p Suppresses Newcastle Disease Virus Replication via Targeting Cellular Suppressors of Cytokine Signaling 3.  Vet Microbiol . 2019; 239:108460

14. Wang X, JiaY, Ren J, Huo N, Liu H, Xiao S, Wang X, YangZ*. Newcastle Disease Virus Nonstructural V Protein Upregulates SOCS3 Expression to Facilitate Viral Replication Depending on the MEK/ERK Pathway.  Front Cell Infect Microbiol, 2019; 9: 317.

15. Wang W, Chang X, Yao W, Wei N, Huo N, Wang Y, Wei Q, Liu H, Wang X, Zhang S, Yang Z*, XiaoS*. Host CARD11 inhibits Newcastle disease virus replication by suppressing viral polymerase activity in neurons.  J. Virol. 2019; 93(24):e01499-19.

16. Bi Y, Jin Z, Wang Y, Mou S, Wang W, Wei Q, Huo N, Liu S, Wang X, Yang Z, Chen H*, Xiao S*. Identification of Two Distinct Linear B Cell Epitopes of the Matrix Protein of the Newcastle Disease Virus Vaccine Strain LaSota.  Viral Immunol.  2019; 32(5): 221-229.

17. Chu Z, Gao X, Liu H, Ma J, Wang C, Lu K, Han Q, Wang Y, Wang C, Adam FEA, Wang X, Xiao S, Yang Z*. Newcastle disease virus selectively infects dividing cells and promotes viral proliferation.  Vet Res.  2019; 50(1):27.

18. Wang X, Jia Y, Wang X, Wang C, Lv C, Li X, Chu Z, Han Q, Xiao S, Zhang S, Yang Z*. MiR-375 Has Contrasting Effects on Newcastle Disease Virus Growth Depending on the Target Gene.  Int J Biol Sci.  2019; 15(1):44-57.

19. Li X, Jia Y, Liu H, Wang X, Chu Z, Hu R, Ren J, Xiao S, Zhang S, Wang X, Yang Z*. High level expression of ISG12(1) promotes cell apoptosis via mitochondrial-dependent pathway and so as to hinder Newcastle disease virus replication.  Vet Microbiol.  2019; 228:147-156.

5. Projects and Funding

[1] National Natural Science Foundation of China (NSFC), No. 31972662, 2020 - 2023, Grant holder.

[2] National Natural Science Foundation of China (NSFC), No. 31572533, 2016 - 2019, Grant holder.